Asymmetric Dimethylarginine and Its Relation As a Biomarker in Nephrologic Diseases
نویسنده
چکیده
It is encouraging to observe that a search for publications on "asymmetric dimethylarginine (ADMA)" in PubMed, as updated on June 2016, yielded >2500 items, 24 years after a splendid paper published by Vallance et al in which the authors proposed that ADMA accumulation could be a cardiovascular risk factor in chronic kidney diseases. ADMA is the endogenous inhibitor of nitric oxide synthase and is related to endothelial dysfunction, which plays an important role in vascular damage elicited by various cardiometabolic risk factors. Although current knowledge suggests that ADMA has critical central roles in renal diseases, there are still unexplained details. The present article aims to provide a review on ADMA and its relation as a biomarker in nephrologic diseases. We aimed to systematize articles in which ADMA levels were assessed in order to clarify its role in many diseases and establish its reference values in different populations.
منابع مشابه
The Study of Serum Asymmetric Dimethylarginine Concentrations in the Different Paraoxonase Phenotypes of Exudative Age-related Macular Degeneration Disease
Background and Aims: Age-related macular degeneration (ARMD) is a degenerative retinal disorder that causes progressive loss of central vision in older adults. The study aimed to determine the effect of asymmetric dimethylarginine (ADMA) as oxidizing metabolite and paraoxonase (PON1) activity within its phenotypes as an antioxidant agent in the development of such multifactorial disease. Mater...
متن کاملO-32: Nitric Oxide and Asymmetric Dimethylarginine Levels of Serum and Peritoneal Fluid in Women with Endometriosis
Background: Endometriosis is a common gynecological syndrom. Its etiology is still not fully understand .A great number of studies reported increase NO concentration, with altered peritoneal immune defence reaction, was involved in pathogenesis of endometriosis. Asymmetric Dimethylarginine is an endogenous competitive inhibitor of NO synthase. Elevated ADMA level is associated with reduced syst...
متن کاملPlasma Asymmetric Dimethylarginine (ADMA) in Relation to Cardiovascular Physiology and Risk Factors of Atherosclerosis
5 TIIVISTELMÄ 7 CONTENTS 8 ABBREVIATIONS 10 LIST OF ORIGINAL PUBLICATIONS 1
متن کاملAsymmetric Dimethylarginine (ADMA) and Endothelial Dysfunction: Implications for Atherogenesis
Atherosclerotic coronary heart disease is the leading cause of morbidity and mortality in industrialized countries, and endothelial dysfunction is considered a precursor phenomenon. The nitric oxide produced by the endothelium under the action of endothelial nitric oxide synthase has important antiatherogenic functions. Its reduced bioavailabilty is the beginning of the atherosclerotic process....
متن کاملShould we measure asymmetric dimethylarginine in patients with coronary artery disease?
In this issue of Clinical Chemistry, Meinitzer et al. (1 ) present data from The Ludwigshafen Risk and Cardiovascular Health Study in which they assess asymmetric dimethylarginine (ADMA) as a cardiovascular biomarker in 3238 patients. Coronary angiography identified 2543 patients with coronary artery disease as well as 695 persons without significant disease. Study participants were followed fo...
متن کامل